Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00404)
Xenobiotics Name
Folic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
135398658
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [1]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Folylpolyglutamate synthase (FPGS) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [4]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [5]
References
1 The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivationRFC as a double edged sword in folate homeostasis. J Biol Chem. 2008 Jul 25;283(30):20687-95.
2 Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J. 2005 Feb;24(2):65-77.
3 Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer. 2008 Oct 1;123(7):1712-20.
4 Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
5 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.

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