Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00415)
Xenobiotics Name
Meclofenamic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4037
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1], [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [1], [2]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [3]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1C1 (AKR1C1) DME Info IC50 = 3.16 microM [1], [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info IC50 = 8.74 microM [1]
Aldo-keto reductase 1C3 (AKR1C3) DME Info IC50 = 0.54 microM [1]
Aldo-keto reductase 1C4 (AKR1C4) DME Info IC50 > 100 microM [1], [2]
References
1 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3 J Med Chem. 2012 Sep 13;55(17):7746-58.
2 Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. Eur J Med Chem. 2013 Apr;62:738-44.
3 Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes. Biochem J. 2000 Mar 15;346 Pt 3:751-8.
4 Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation. Free Radic Biol Med. 2009 Aug 15;47(4):364-74.

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