Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00464)
Xenobiotics Name
Bifonazole
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2378
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1], [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.8 microM [3]
References
1 Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94.
2 AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicol Sci. 2014 May;139(1):198-209.
3 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.

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