Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00468)
Xenobiotics Name
Fadrozole
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
59693
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [1]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Steroid 11-beta-hydroxylase (CYP11B1) DME Info IC50 = 0.0063 microM [1]
Aldosterone synthase (CYP11B2) DME Info IC50 = 0.0008 microM [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info IC50 > 5 microM [2]
Aromatase (CYP19A1) DME Info IC50 = 0.000004 microM [3]
References
1 Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem. 2014 Jun 26;57(12):5179-89.
2 Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11beta-hydroxylase inhibition. J Med Chem. 2013 Feb 28;56(4):1723-9.
3 Recent progress in the discovery of next generation inhibitors of aromatase from the structure-function perspective. J Med Chem. 2016 Jun 9;59(11):5131-48.

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