Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00521)
Xenobiotics Name
Phenolphthalein
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug Marketed but Withdrawn from Market
Structure
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3D MOL 2D MOL
PubChem CID
4764
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [1]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Thymidylate synthase (TYMS) DME Info Ki = 1.2 microM [3]
References
1 Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents. Biol Chem. 2007 Oct;388(10):1069-81.
2 Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
3 Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67.

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