Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00577)
Xenobiotics Name
Pimagedine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
2146
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Amiloride-sensitive amine oxidase (AOC1) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Amiloride-sensitive amine oxidase (AOC1) DME Info Ki = 0.14 microM [1]
Nitric oxide synthase inducible (NOS2) DME Info IC50 = 101 microM [3]
References
1 Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. J Biol Chem. 1994 Apr 1;269(13):9921-5.
2 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
3 Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8.

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