Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00578)
Xenobiotics Name
Arecoline
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
2230
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1A1 (AKR1A1) DME Info Homo sapiens [1]
Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DME Info Homo sapiens [1]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [1]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Metallothionein-1A (MT1A) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
References
1 Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci. 2007 Nov;100(1):66-74.
2 The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncol. 2008 Feb;44(2):180-6.
3 Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol. 2006 Jul;42(6):561-8.

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