Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00630)
Xenobiotics Name
Sorbinil
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
337359
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1B1 (AKR1B1) DME Info IC50 = 0.067 microM [1]
Small intestine reductase (AKR1B10) DME Info IC50 = 9.6 microM [2]
References
1 Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids. J Med Chem. 1986 Nov;29(11):2347-51.
2 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90.

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