Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00654)
Xenobiotics Name
Icariin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5318997
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Phosphodiesterase 5A (PDE5A) DME Info IC50 = 5.9 microM [1]
References
1 Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7.
2 Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul Pharmacol. 2007 Jul;47(1):18-24.

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