Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00667)
Xenobiotics Name
PD-0325901
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
9826528
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [3]
References
1 Effects of water soluble PM2.5 extracts exposure on human lung epithelial cells (A549): A proteomic study. J Appl Toxicol. 2014 Jun;34(6):675-87.
2 Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China. Toxicol Lett. 2014 Jul 3;228(1):25-33.
3 Transcriptome analysis of airborne PM2.5-induced detrimental effects on human keratinocytes. Toxicol Lett. 2017 May 5;273:26-35.

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