Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00787)
Xenobiotics Name
Lithocholic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
9903
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4], [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [6]
References
1 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
2 Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
3 Anti-inflammatory action of sulfated glucosamine on cytokine regulation in LPS-activated PMA-differentiated THP-1 macrophages. Inflamm Res. 2011 Dec;60(12):1131-8.
4 NFB-dependent increase of kynurenine pathway activity in human placenta: inhibition by sulfasalazine. Placenta. 2010 Nov;31(11):997-1002.
5 Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Arch Toxicol. 2017 Apr;91(4):1915-1924.
6 Cytotoxic and anti-inflammatory effects of onion peel extract on lipopolysaccharide stimulated human colon carcinoma cells. Food Chem Toxicol. 2013 Dec;62:199-204.

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