Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00834)
Xenobiotics Name
Copper
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
23978
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Myeloperoxidase (MPO) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [4]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5], [6]
DME(s) Induced by This Xenobiotics
Amiloride-sensitive amine oxidase (AOC1) DME Info Homo sapiens [7]
Catalase (CAT) DME Info Homo sapiens [8]
Aromatase (CYP19A1) DME Info Homo sapiens [9]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [9]
Metallothionein-2A (MT2A) DME Info Homo sapiens [10], [11]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [12]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [13]
References
1 Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease. J Environ Pathol Toxicol Oncol. 2009;28(3):209-21.
2 Does mercury promote lipid peroxidation? An in vitro study concerning mercury, copper, and iron in peroxidation of low-density lipoprotein. Biol Trace Elem Res. 2004 Nov;101(2):117-32.
3 Effect of copper intrauterine device on the cyclooxygenase and inducible nitric oxide synthase expression in the luteal phase endometrium. Contraception. 2011 Dec;84(6):637-41.
4 Oxidative inactivation of paraoxonase--implications in diabetes mellitus and atherosclerosis. Biochim Biophys Acta. 2005 Sep 15;1725(2):213-21.
5 Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. J Nutr. 2003 Jan;133(1):28-31.
6 Impaired copper and iron metabolism in blood cells and muscles of patients affected by copper deficiency myeloneuropathy. Neuropathol Appl Neurobiol. 2014 Dec;40(7):888-98.
7 Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79.
8 Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res Mol Brain Res. 2005 Apr 4;134(2):323-32.
9 High copper levels in follicular fluid affect follicle development in polycystic ovary syndrome patients: population-based and in vitro studies. Toxicol Appl Pharmacol. 2019 Feb 15;365:101-111.
10 Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2). J Biol Chem. 1988 Feb 25;263(6):2679-84.
11 Heavy metal responses of the human metallothionein isoform genes. Yakugaku Zasshi. 2007 Apr;127(4):665-73.
12 Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience. 2006 Nov 17;143(1):63-72.
13 Role of hepatocyte nuclear factor 4alpha in controlling copper-responsive transcription. Biochim Biophys Acta. 2011 Jan;1813(1):102-8.

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