Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01082)
Xenobiotics Name
CP-461
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
6445781
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [2]
References
1 Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.
2 Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. Cancer Res. 2005 Sep 15;65(18):8442-7.

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