Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01117)
Xenobiotics Name
27-hydroxycholesterol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
123976
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
References
1 Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Biochim Biophys Acta. 2010 Jan;1801(1):31-41.
2 Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 2008 Jan 18;283(3):1445-55.
3 Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. PLoS One. 2014 May 6;9(5):e96795.

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