Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01171)
Xenobiotics Name
7,8-diacetoxy-4-methylcoumarin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
390798
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [2]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [2]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
References
1 Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway. Chem Biol Interact. 2009 May 15;179(2-3):363-74.
2 Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells. Chem Biol Interact. 2013 Nov 25;206(2):327-36.

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