Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01236)
Xenobiotics Name
Carbenoxolone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
636403
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [2], [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info IC50 = 0.083 microM [1]
References
1 Arylsulfonamidothiazoles as a new class of potential antidiabetic drugsDiscovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45(18):3813-5.
2 Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Steroids. 2006 Oct;71(10):895-901.
3 Anti-diabetic and anti-inflammatory effect of a novel selective 11beta-HSD1 inhibitor in the diet-induced obese mice. Eur J Pharmacol. 2013 Dec 5;721(1-3):70-9.

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