Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01328)
Xenobiotics Name
Hemin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
121225420
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [2]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3]
References
1 Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. Biochem J. 2001 Jun 1;356(Pt 2):613-9.
2 Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells. Biochem Pharmacol. 2004 Sep 15;68(6):1269-77.
3 The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth. Toxicol Appl Pharmacol. 2019 Jul 1;374:77-85.

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