Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01331)
Xenobiotics Name
Homocysteine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
91552
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [2]
Glutathione reductase (GSR) DME Info Homo sapiens [1]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [4]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6]
References
1 Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection. Chem Biol Interact. 2012 Oct 25;200(1):1-10.
2 Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem. 2005 Apr 22;280(16):15518-25.
3 Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells. Cell Biochem Biophys. 2006;45(2):137-45.
4 Erythrocyte membrane acetylcholinesterase activity in subjects with MTHFR 677C--&gt;T genotype. Clin Chem Lab Med. 2006;44(1):23-7.
5 Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS. Cardiovasc Res. 2008 Oct 1;80(1):151-8.
6 Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes. BMC Complement Altern Med. 2015 Mar 13;15:61.

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