Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01422)
Xenobiotics Name
Paraquat
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
15939
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2], [3]
Glutamine synthetase (GLUL) DME Info Homo sapiens [4]
Glutathione reductase (GSR) DME Info Homo sapiens [5]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [6]
Lactoperoxidase (LPO) DME Info Homo sapiens [6]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6]
References
1 Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009 Nov;45(16):2882-92.
2 Development of long noncoding RNA-based strategies to modulate tissue vascularization. J Am Coll Cardiol. 2015 Nov 3;66(18):2005-2015.
3 Gene expression profiling identifies cell proliferation and inflammation as the predominant pathways regulated by aryl hydrocarbon receptor in primary human fetal lung cells exposed to hyperoxia. Toxicol Sci. 2016 Jul;152(1):155-68.
4 Ozone inactivates cyclooxygenase in human tracheal epithelial cells without altering PGHS-2 mRNA or protein. Am J Physiol. 1997 May;272(5 Pt 1):L879-87.
5 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
6 Aryl hydrocarbon receptor is an ozone sensor in human skin. J Invest Dermatol. 2009 Oct;129(10):2396-403.

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