Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01483)
Xenobiotics Name
Thioctic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
864
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [1], [2]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [3]
Glutathione reductase (GSR) DME Info Homo sapiens [4]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5], [6]
References
1 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. Arch Biochem Biophys. 2005 Mar 1;435(1):50-5.
2 PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. Cardiovasc Res. 2010 May 1;86(2):302-10.
3 Thioredoxin reductase is the major selenoprotein expressed in human umbilical-vein endothelial cells and is regulated by protein kinase C. Biochem J. 1999 Aug 15;342 ( Pt 1):111-7.
4 Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis. Environ Mol Mutagen. 2009 Jan;50(1):46-59.
5 Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation. Chem Biol Interact. 2010 Mar 30;184(3):413-22.
6 Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFB p65 signal pathway. Toxicol In Vitro. 2015 Oct;29(7):1766-78.

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