Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01491)
Xenobiotics Name
Tributyltin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
57373047
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [1]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [5]
Aromatase (CYP19A1) DME Info Homo sapiens [6]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [7]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [8]
References
1 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
2 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
3 Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. Blood. 2001 Jan 1;97(1):264-9.
4 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
5 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
6 Effects of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells. J Cell Physiol. 2000 Jan;182(1):50-61.
7 The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma. Mol Cancer Ther. 2007 Apr;6(4):1300-9.
8 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.

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