Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1003)
DME Name Peroxidase (katG), Desulfofarcimen acetoxidans
Synonyms Catalase-peroxidase; Bacterial peroxidase/catalase; Bacterial katG; Dtox_0871
Gene Name katG
UniProt ID
C8W2A6_DESAS
EC Number    EC: 1.11.1.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.21
Lineage    Species: Desulfofarcimen acetoxidans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptococcaceae
Genus: Desulfofarcimen
Species: Desulfofarcimen acetoxidans
Subspecies: Desulfofarcimen acetoxidans DSM 771
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MYEKEKCPVTGRTNNAIAGAANSNRDWWPNQLNLKILHQNSNLSNPMALEFNYAEEFKKL
DLDALKKDLYALMTDSQDWWPADYGHYGPFFIRMAWHSAGTYRTNDGRGGAGKGTQRFAP
LNSWPDNVNLDKARRLLWPIKQKYGSKISWADLMILAGNCALESMGLKTFGFSGGREDVW
EPQEDIYWGTESEWLGDNRYSGDRELENPLAAVQMGLIYVNPEGPNGNPDPVASGRDVRE
TFARMAMNDEETVALVAGGHTFGKCHGMGDPTLVGPEPEAAGIEEQGLGWKSSFGSGKGG
DTISSGIEGAWKPNPTKWDMGYLNMLFKYEWELVKSPAGAHQWLAKDVDEEDMVIDAHDP
SKKHRPMMTTADLSLRYDPIYEPISRRYQQNPEEFTDAFARAWFKLTHRDMGPRSRYLGA
EVPEEELIWQDPVPAIDHELVDEHDIEDLKSKILASGLSVSQLVSTAWASASTFRGSDKR
GGANGARIRLAPQKDWEVNQPAQLNTVLNVLEKIIAEFNSAQTGPKKISLADLIVLGGCA
GIEQAAKNAGCNVSVPFIPGRTDASQEQTDVQSFSVLEPIADGFRNYQKTKYSASAEELL
VDRAQLLTLTAPEMTVLLGGMRVLNTNHGQSQHGVFTKRPEALTNDFFVNLLDMSTTWKA
ISEDENVFEGRDRSTGEIKWTGTSVDLIFGSNSQLRAIAEVYACDDSQSKFINDFVSAWN
KVMNADRFDLS
Pathway Biosynthesis of secondary metabolites (dae01110 )
Metabolic pathways (dae01100 )
Phenylalanine metabolism (dae00360 )
Tryptophan metabolism (dae00380 )
Function This enzyme is with both catalase and broad-spectrum peroxidase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Benzyl benzoate
 Drug Info Approved Scabies ICD11: 1G04 [1], [2]
References
1 Peroxidase activity in the sulfate-reducing bacterium Desulfotomaculum acetoxidans DSM 771. Pol J Microbiol. 2010;59(4):249-55.
2 The uptake and accumulation of iron by the intestinal bacterium Desulfotomaculum acetoxidans DSM 771. Folia Biol (Krakow). 2005;53(1-2):79-81.

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