Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1014)
DME Name Beta-lactamase (blaB), Acidaminococcus intestini
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; ACDG_00016
Gene Name blaB
UniProt ID
C0W968_9FIRM
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Acidaminococcus intestini     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Acidaminococcales
Family: Acidaminococcaceae
Genus: Acidaminococcus
Species: Acidaminococcus intestini
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDT
RFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSAS
LRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQM
VKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDI
AVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
References
1 ACI-1 beta-lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages. Environ Microbiol. 2018 Jun;20(6):2288-2300.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.