Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1021)
DME Name N-acylhomoserine lactone acylase (lacA), Acidovorax ebreus
Synonyms Acyl-homoserine lactone acylase; Acyl-HSL acylase; AHL acylase; AHL amidase; AHL-acylase; Protein related to penicillin acylase; AVS7_00617
Gene Name AVS7_00617
UniProt ID
A0A0A1VBK6_9BURK
EC Number    EC: 3.5.1.97     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amide hydrolase
EC: 3.5.1.97
Lineage    Species: Acidovorax ebreus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Comamonadaceae
Genus: Acidovorax
Species: Acidovorax ebreus
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRESIHRGAWPRSVLTLAAVAALAACGGSGGGDGSTYSAEIRRTTMGVPHIKAGNWGSAG
YGFGYVQAQDNLCTMADSFLTYRGERSRHLGGSAQLVYNSTLGRPRNIDSDFFHRHVISD
EAVDRTMAAQPAKLLQMVEGFAAGYNRYVREAKAGGSAHAACRSEAWVQPITARDVWRRI
YAANLAGGYSNFAEAIANAQPPQAKAGAQEPAAFEPGRTRAPSLQVGGELGVGSNMYGFG
TAATGEGSGVLFGNPHWYWKGPDRFYQAQLTIDGEANVSGVSFLGLPVIQIGFNDSVAWS
HTVSTARRFGFFQLSLVQGEPTSYLRDGVPVKMKPATITVPSRNADGSVSDVTRTLYHSE
FGPLVNLAGLNPALAWSQGTAFAIRDINGENFRTLRTWMRWNQAKSLDEFIAIQKEEASI
PWVNTVAVGRGSAKAWYADIGAVPNVSPAQTAACTTPFGMAVGQALPNVPFFDGSRSECD
WLTDADSVQKGAVGVSRMPSLQRDDYVGNMNDSYWLANVHAPLTGYPAIFGPAGTSAQTL
RTRMGHTMALERLAGTDGYAGNKATSAVVREMVLGSRVFSAERFKDEVLDLICTPAQWTV
NGAAVDAAQACAVLAAWDNRGRKDSRGSHLWDEFWSRVPTASLFTVPFSAADPLNTPRGI
NAAAADALRQAMATAIARVGQSGYALDAPRGEVLYATRGGTRLPLYGGCGAMGYFTITCS
ENDITQGGYSMDGQPNASNSYMQVVSFPASGVQAHTFLTFSLSDDPASPHHGDYTKAYSA
GQWLRVPFTEAEITGNADYRTATVKE
Structure
4YF9 ; 4YFA ; 4YFB ; 5C9I
Function This enzyme catalyzes the conversion of N-acyl-L-homoserine lactone to N-acyl-L-homoserine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          6 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [1]
Carbenicillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
Cefadroxil
 Drug Info Approved Acute tonsillitis ICD11: CA03 [1]
Cefalexin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17.

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