Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1026)
DME Name Beta-lactamase (blaB), Bacteroides uniformis
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; cblA
Gene Name cblA
UniProt ID
BLAC_BACUN
Gene ID
31505337
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Bacteroides uniformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides uniformis
Subspecies: Bacteroides uniformis B 371
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKAYFIAILTLFTCIATVVRAQQMSELENRIDSLLNGKKATVGIAVWTDKGDMLRYNDHV
HFPLLSVFKFHVALAVLDKMDKQSISLDSIVSIKASQMPPNTYSPLRKKFPDQDFTITLR
ELMQYSISQSDNNACDILIEYAGGIKHINDYIHRLSIDSFNLSETEDGMHSSFEAVYRNW
STPSAMVRLLRTADEKELFSNKELKDFLWQTMIDTETGANKLKGMLPAKTVVGHKTGSSD
RNADGMKTADNDAGLVILPDGRKYYIAAFVMDSYETDEDNANIIARISRMVYDAMR
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          5 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [2]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [2]
Cephalothin
 Drug Info Approved Infectious cystitis ICD11: GC00 [2]
Piperacillin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Cefaloridine
 Drug Info Phase 4 Staphylococcus infection ICD11: 1B73 [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          5 Drugs
Ampicillin
 Drug Info Approved Endocarditis Km = 4.4 microM [2]
Penicillin G
 Drug Info Approved Diphtheria Km = 3.5 microM [2]
Cephalothin
 Drug Info Approved Infectious cystitis Km = 113 microM [2]
Piperacillin
 Drug Info Approved Pneumocystis pneumonia Km = 0.58 microM [2]
Cefaloridine
 Drug Info Phase 4 Staphylococcus infection Km = 177 microM [2]
References
1 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
2 Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61.

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