Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1036)
DME Name Cardiac glycoside reductase 2 (cgr2), Eggerthella lenta
Synonyms Cardiac glycoside reductase operon protein 2; Cardenolide reductase; Digoxin reductase; cgr2
Gene Name cgr2
UniProt ID
CGR2_EGGLE
Gene ID
40923314
EC Number    EC: 1.3.2.-     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.3.2.-
Lineage    Species: Eggerthella lenta     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
Species: Eggerthella lenta
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MEYGKCRGIERGMGRRDFLKAATLLGATAAGAGMLAGCAPKSASEAQAQTAPAATGGLDP
ADVDWKYETDVVIVGSGSGGTCAAIEAAEAGADVVVFEKDKAMYGGNSALCGGYMLAAGW
STQEEITGYAGDTGEAFANQMLRWSQGLGNQDMIREACLRSGEAVDWMMDTGRTYEGASP
LPPVWSCGDTEADVVPRSVYNHNAYGATEGHMATLKKRAESLSNIEIEMGCEVAHILKNA
EGSVIGVQLADGSFAKARKGVVMACASVDNNLEMSKDLGLMQNVWGLTLEGAGLLAPGNP
DMDSNTGDGVRMLREIGAELCMQQAVCMNDSIYVGGISDWGMSEILGKDVNIHDSSNIDA
ILVDKTGRRFCQDDAEWGYVMHECAQAAWKQGFTPDDPTTGYIFYVYDATGAPFFEMKGH
TPDTCDTTFSADSVDGLAEFIGCDPTALASEVERWNSFCEAGLDADFGRRANMAPIATPP
FYCDVVRPGPMGTFAGAKSNVEAEIIGLDGNPIPRLYGAGCIIGGNVSGAFYFGCGWSIT
NTVVWGREAGRNVAALEPWE
Function This enzyme serves as the terminal electron reductase partner to Cardiac glycoside reductase 1 (Cgr1) by forming an complex with Cgr1 and receiving electrons from Cgr1 at the active site FAD redox cofactor.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000856 Digoxin Dihydrodigoxin Reduction - Reduction Digoxin [1], [2]
References
1 Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.
2 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.