Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1099)
DME Name Arylamine N-acetyltransferase (NAT), Vibrio cholerae
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; nat; NCTC10741_01829; BVX91_14895
Gene Name nat
UniProt ID
A0A3P8LE58_TSUPA
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Vibrio cholerae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio cholerae
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MNDDAAWGAPALDLPRYLHRIGLQAPPAPDLAGLSTLVRAHALTLPWENFDAVRGIPGEL
TIDALQRRMIEGRRGYGCTGHVPLLAAALQRTGFRFGAASGRVLVDGGPSASTHALLIVE
VDGAPHLAEVGFGAVPLAPLRLESGLEQDAGGWRYRLTAEAVGFGEEWRLDFLDPSSGQW
RPQYRFALADRTWSDLRMTNFYVATSPHSPFRGRLMAVVNRPGERHVLTRDAVISTRPDG
FRETVPYVAADRRAILAESFAIDLPEDEAAALAAVSGS
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
PG-490
 Drug Info Phase 3 Diabetes mellitus ICD11: 5A10 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
Nitrobenzanthrone
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Aminobenzoic acid
 Drug Info Investigative Penile fibromatosis ICD11: GB06 [3]
Asacolitin
 Drug Info Investigative Inflammatory bowel disease ICD11: DD72 [4]
References
1 Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154.
2 Carcinogenic 3-nitrobenzanthrone but not 2-nitrobenzanthrone is metabolised to an unusual mercapturic acid in rats
3 Human placental transfer and metabolism of p-aminobenzoic acid
4 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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