Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1139)
DME Name Beta-galactosidase (bgaB), Victivallis vadensis
Synonyms Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; C8D82_10873
Gene Name bgaB
UniProt ID
A0A2U1B4D0_9BACT
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Victivallis vadensis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Lentisphaerae
Class: Lentisphaeria
Order: Victivallales
Family: Victivallaceae
Genus: Victivallis
Species: Victivallis vadensis
Subspecies: Victivallis vadensis ATCC BAA-548
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTVIRNFRRILHGGDYNPDQWLHVPGTVDRDFELMDEAHCNTFSVAIFSWAQLEPEPDRF
EFGWLDDIFERCGKSGKKLFLATPSASKPAWLAQRWPDSCRMDRDGTRQRWGVRQNSCFA
SPGFRERVRLINRKLAERYADHPALGGWHISNEYHGECACELCRNRFYDYLKQRYGTLEK
LNQVYWSAFWGHTFTDWKQVEPFDHSMDAAALDWRRFCSDAVVEFFRMEIDAVREFSDAP
VTTNMMGLFPTLDYWKFAPLCDFICDDCYPTWYDGDTEREAAWLSLLHDMHYTMLDKPFV
MMESCPGIPNYKPYPKLRRPGEFEREMLLALGHGADGTLYFQWRKGRNNCEKFHGAVVGH
DGTDRTMVFRQVAAYGEKLERIAGLADAAKKPEAAVVYDWESNWAFEQCNCAGGKEVKQW
DATAISHYRALWNCNIDLAVIDSEQDFSRYKLLVAPMLFMFKPGVLERFRSFVEQGGTLV
ATYFSGYVDENNGCFLGGNPGGAAGRELFGVWSEDFDGLQPTTRQSIVWKGKSYPVTDYA
ELLHAEGAEVEAVYGDDFYAGTPAVTRKRAGKGNVIYLGARTGMEFLNDFYGALLKESGV
EPVLAGLPETVRAARRSAVSGGDYFFLYNLSGKEQPVKLPEAMEDVWNGGGAADTVTLPP
NGATVLYRA
Function This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Lactose
 Drug Info Phase 1 Lactose intolerance ICD11: 5C61 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PNA-D-glucopyranoside
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40.

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