Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1147)
DME Name Beta-glucosidase (bglA), Eubacterium cellulosolvens
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; DCY19_10210
Gene Name DCY19_10210
UniProt ID
A0A351PC96_9FIRM
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Eubacterium cellulosolvens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium cellulosolvens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFRDDFVWGVASSAYQVEGTDPEDGRGKCVWDVFTEEGHIHENQNAYTACDHMHRYKEDY
ALMRQLGIKAYRFSMNWARILPEGTGRVNEKAIAMYRDMIVTMKENGITPYITMFHWELP
QALQVKGGWLNPQIVDWFGEYARVIAENFADLCDYFITINEPQCVVGLGHLSAVHAPGVR
HTVTDTFQIAHNLLKAHGQAVINLRKYAGRPIKVGYAPTGGVAYPYTDSPEDIEAARKVY
FGFYNPLDNWTWNVAWFSDPVFLGHYPEEGLKKFKKYLPDITKEDMELIHQPLDFMGQNI
YNGYFVRAGKDGEPEFVDRAPGFPRTAAGWPVTPRAFYYGIKFLYERYKLPLYITENGMS
CHDLVSSDHKVHDPNRITFLESYIKGMEKAIDEGADVRGYFEWTFLDNFEWADGYTQRFG
MVYVDFTTQERIPKDSAYWYSKVIESNGRCLPETGILWC
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
SC-46553
 Drug Info Phase 3 Cerebral stroke ICD11: 8B11 [1], [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
HY-N0040
 Drug Info Preclinical Rotavirus gastroenteritis ICD11: 1A22 [2]
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [1], [2]
References
1 Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998 Oct;50(10):1155-60.
2 Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.

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