Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1155)
DME Name Beta-galactosidase (bgaB), Leptotrichia goodfellowii
Synonyms Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; JCM16774_1906; Lactase
Gene Name bgaB
UniProt ID
A0A510JCD5_9FUSO
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Leptotrichia goodfellowii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Leptotrichia
Species: Leptotrichia goodfellowii
Subspecies: Leptotrichia goodfellowii CCUG 32286
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNKWEDFNILSENTMEPRNHFFRYENLEKAKTFNRYYSENFLLLNGIWKFKYFKNPHEVL
EEYHSQITADREIQVPNMWQFEGYGQPHYTDEGFPFPIDFPYVSTDNPTGLYQRYFYLSK
EFKNKDIILKAEGIESYYELYINGHYVGLNKGSRLITEFDITDFVNISKENLISIKVLQW
SDSTYLEDQDMWWISGIFRDIYIYSKNRFCIEKYVVKTEMKNDYKDSDLIIDLELNTEKF
LGKNLEIEFTLYNEKEKIFSEKIVPKKKNIKLKKSIKKIIEWNPENPYLYDLFIILRKDK
KIIEVIPQKVGFRYIEVKKGLMYLNGKYFMMHGVNRHDNDHISGRTVGFERMEKDIILMK
QNNINSVRTAHYPNSPRFYELCDKYGLMVLSEMDIETHGFVNTDDFNMLINNEKYKKMFV
SRVVRQVISQINHPSIIIWSLGNESGYGVNVTHMTNEIKKVDTTRLIHYEEDRYAEDVDI
ISTMYSRVQMMDNFGRFPSDKPRIICEYAHAMGNGPGGLKEYQEVFYKYPSIQGHFVWEW
CDHGIYDKERDIYKYGGDYEDYPNNLNFCMDGLIFSNQKEGPGLKEYKQVISPVLIKKIS
DIEYKVINRYWFSNLKDIKIYYEIFNGKKLTECNELENIENGSIIKFPRKIVNASIINFK
VYKKNKTDYSAENHLLSVYQFQLEEKKQTYEKDNKIPEFHKITENNNEIVITGKNFSIKF
SKLNGKLISYNYSGLELIKKPGSINLYKPVIDNHKKENLKWWLPFYFSVIQEHFRKMKIV
KEKNKVKISVNSILAPPVYDFGLNCEYEYEIYGNGQINIKLKGKKYGKFLGIIPKIGFEI
GLNKDLQNVKYYGRGENENYTDSKEASIIGFYKTTVDNMFINYPYPQDNGNHQDTKELYL
TNHFGQGMSVKSENGLNFSAWNYTKENIDKAKHPDELIKSDFITLNLDYKILGLGSNSWG
SEVLETYRVYLEDFEYGFSINTYND
Function This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Mannose
 Drug Info Investigative Discovery agent ICD: N.A. [1], [2]
References
1 Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592.
2 Leptotrichia species in human infections II. J Oral Microbiol. 2017 Sep 15;9(1):1368848.

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