Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1165)
DME Name Phloroglucinol reductase (PHGR), Eubacterium oxidoreducens
Synonyms Phloro-glucinol reductase; Dihydrophloroglucinol:NADP+ oxidoreductase; PGR; PGRcl; PGRde; PGReu
Gene Name PHGR
UniProt ID
PHGR_EUBOX
EC Number    EC: 1.3.1.57     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.57
Lineage    Species: Eubacterium oxidoreducens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Eubacteriaceae
Genus: Eubacterium
Species: Eubacterium oxidoreducens
Subspecies: Eubacterium oxidoreducens G41
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MVNVKKEFVDNMFSVKGKVALVTGATGALGCVLSKAYGYAGAKVFMTGRNEKKLQALEAE
FKAEGIDCAYGVADPADEAQVDAMITACVAQYGEVNILAVTHGFNKPQNILEQSVADWQY
IMDADCKSVYVVCKYVAQQMVDQGKGGKIVVVTSQRSKRGMAGYTGYCTSKGGADLMVSS
MACDLSAKYGINVNSICPTVFRSDLTEWMFDPESAVYQNFLKREPIGRLAEPEDFVGYAL
FLSSDASNYITGANCDCSGGYLTC
Function This enzyme is involved in the gallate anaerobic degradation pathway in bacteria.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Phloroglucinol
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41. J Biol Chem. 1989 Mar 15;264(8):4423-7.

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