Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1166)
DME Name Amylosucrase (AMS), Deinococcus geothermalis
Synonyms Sucrose-1,4-alpha-glucan glucosyltransferase; Sucrose-glucan glucosyltransferase; Sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase; Dgeo_0572
Gene Name AMS
UniProt ID
Q1J0W0_DEIGD
EC Number    EC: 2.4.1.4     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.4
Lineage    Species: Deinococcus geothermalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Deinococcusthermus
Class: Deinococci
Order: Deinococcales
Family: Deinococcaceae
Genus: Deinococcus
Species: Deinococcus geothermalis
Subspecies: Deinococcus geothermalis HLHK9
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MLKDVLTSELAAQVRDAFDDDRDAETFLLRLERYGEDLWESLRAVYGDQVRALPGRLLEV
MLHAYHARPAELRRLDEARLLRPDWLQRPEMVGYVAYTDRFAGTLKGVEERLDYLEGLGV
KYLHLMPLLRPREGENDGGYAVQDYRAVRPDLGTMDDLSALARALRGRGISLVLDLVLNH
VAREHAWAQKARAGDPKYRAYFHLFPDRRGPDAFEATLPEIFPDFAPGNFSWDEEIGEGE
GGWVWTTFNSYQWDLNWANPDVFLEFVDIILYLANRGVEVFRLDAIAFIWKRLGTDCQNQ
PEVHHLTRALRAAARIVAPAVAFKAEAIVAPADLIHYLGTRAHHGKVSDMAYHNSLMVQL
WSSLASRNTRLFEEALRAFPPKPTSTTWGLYVRCHDDIGWAISDEDAARAGLNGAAHRHF
LSDFYSGQFPGSFARGLVFQYNPVNGDRRISGSAASLAGLEAALETGDPGRIEDAVRRLL
LLHTVILGFGGVPLLYMGDELALLNDYAFEDVPEHAPDNRWVHRPQMDWALAERVRQEPS
SPAGRVNTGLRHLLRVRRDTPQLHASIESQVLPSPDSRALLLRRDHPLGGMVQVYNFSEE
TVMLPSHVLRDVLGDHVQDRLSGSAFRLDRPTVRLEGYRALWLTAGEAPA
Structure
3UCQ ; 3UER
Pathway Metabolic pathways (dge01100 )
Starch and sucrose metabolism (dge00500 )
Function This enzyme catalyzes the glucosylation of flavonoids with sucrose as a sugar donor.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Flutamide
 Drug Info Approved Prostate cancer ICD11: 2C82 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
RTR-001007
 Drug Info Phase 1 Diabetes mellitus ICD11: 5A10 [2], [3]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Hydroxydaidzein
 Drug Info Investigative Discovery agent ICD: N.A. [4], [2]
References
1 Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
2 The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet. 2009 Mar;5(3):e1000416.
3 Glycosylation enhances the physicochemical properties of caffeic acid phenethyl ester. J Microbiol Biotechnol. 2017 Nov 28;27(11):1916-1924.
4 Potential industrial production of a well-soluble, alkaline-stable, and anti-inflammatory isoflavone glucoside from 8-hydroxydaidzein glucosylated by recombinant amylosucrase of Deinococcus geothermalis. Molecules. 2019 Jun 15;24(12). pii: E2236.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.