Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1172)
DME Name Aminoglycoside N-acetyltransferase (aacC2), Acinetobacter baumannii
Synonyms Aminoglycoside N(6')-acetyltransferase type 1; Aminoglycoside resistance protein; AAC(6')-Ih
Gene Name aacC2
UniProt ID
AAC6_ACIBA
Gene ID
23000000
EC Number    EC: 2.3.1.82     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.82
Lineage    Species: Acinetobacter baumannii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MNIMPISESQLSDWLALRCLLWPDHEDVHLQEMRQLITQAHRLQLLAYTDTQQAIAMLEA
SIRYEYVNGTQTSPVAFLEGIFVLPEYRRSGIATGLVQQVEIWAKQFACTEFASDAALDN
QISHAMHQALGFHETERVVYFKKNIG
Structure
4E8O
Function This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Neomycin
 Drug Info Approved Hepatic encephalopathy ICD11: DB99 [1]
Netilmicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
Tobramycin
 Drug Info Approved Conjunctivitis ICD11: 9A60 [1]
References
1 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.

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