Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1195)
DME Name Beta-mannosidase (manB), Bacteroides salyersiae
Synonyms Mannan endo-1,4-beta-mannosidase; Beta-mannoside mannohydrolase; BetaMANNOS1; HMPREF1071_04441
Gene Name manB
UniProt ID
I8XYI3_9BACE
EC Number    EC: 3.2.1.78     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.78
Lineage    Species: Bacteroides salyersiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides salyersiae
Subspecies: Bacteroides salyersiae CL02T12C01
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKNSFLIGIIIISFFSCKTPMKNKMPTDPQATHETVALYNRLFNLAEKGIMLGHQDDPLY
GHGWYGEQDRSDVKGMIGDYPAIFGFELGHIELDSEYSLDSVYFSQIKKHVKEHHARGGI
SSFSWHADNIATGNSTWDCAQDTVVRSILPGGSLHKEYLVWLERLANFFLDLKDENGAYI
PVIFRMYHEHTGDWFWWSSQQSTPEEYKQLWIMTCDYLQKTKQVHHLLYAYSSSNVQSEE
HYLERYPGDQYVDILGFDHYLKGREQKNVEQYKIDFERNIKIVTKCAEQSGKLPVIGETG
EESIWDPTYFTNVVYPIINKYKLGWILFWRNAWEPDKPNHYYLPYPGHSSESDFKQFVDQ
PLILTNKDVYQQ
Function This enzyme catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
W-201259
 Drug Info Preclinical Salmonella infection ICD11: 1A09 [1]
Man-b-4MU
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Mannotetraose
 Drug Info Investigative Alzheimer disease ICD11: 8A20 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          3 Drugs
W-201259
 Drug Info Preclinical Salmonella infection Kcat/Km = 0.0022 s-1microM-1 [1]
Man-b-4MU
 Drug Info Investigative Discovery agent Km = 1050 microM [1]
Mannotetraose
 Drug Info Investigative Alzheimer disease Kcat/Km = 0.0045 s-1microM-1 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005856 Man-b-4MU Unclear Unclear - Unclear Man-b-4MU [1]
MR005850 Mannotetraose Unclear Unclear - Unclear Mannotetraose [1]
MR007001 W-201259 Unclear Unclear - Unclear W-201259 [1]
References
1 Structure and function of Bs164 beta-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020 Mar 27;295(13):4316-4326.

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