Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1198)
DME Name Lactate racemase (Lsa784), Lactobacillus sakei
Synonyms Lactate racemization operon protein LarA; LAS9624_00840; LSAJ112_140075; Lar; Lsa784; lsa784
Gene Name Lsa784
UniProt ID
Q3BCH3_LACSK
Gene ID
33974450
EC Number    EC: 5.1.2.1     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Hydroxy acid racemase/epimerase
EC: 5.1.2.1
Lineage    Species: Lactobacillus sakei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus sakei
Subspecies: Lactobacillus sakei NRIC 1071(T)
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MVAIKLPYDQKIITANIADANFAGKLVSQAATYQNPLSEAETVEQSLDNPIDSPKLEELA
KGKKNIVIISSDHTRPVPSHIMTPILLRRIRSVAPDARIRILVATGFHRPSTHEELVNKY
GEEIVANEEIVMHISTDDSSVVKIGQLPSGGDCIINKIAVEADLLISEGFIESHFFAGFS
GGRKSILPGVASYKTIMANHSGEFINSHYSRTGNLMHNPVHKDMVYAAKTAGLKFILNVV
LDEDKHIIGSFAGNLETAHKKGCDFVESLSEVDKIDCDIAISTNGGYPLDQNIYQAVKGM
TAAEATNKQGGVIIMVAGARDGHGGDGFYHNIADVKDPKEFLDQAINTPRLETVPDQWTS
QILARILVQHHVIFVSDLVDPQLITDMHMELATSLDAALERAYAIEGADAKVTVIPDGLG
VIVK
Function This enzyme contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
D-lactic acid
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 The effect of sodium acetate on the growth yield, the production of L- and D-lactic acid, and the activity of some enzymes of the glycolytic pathway of Lactobacillus sakei NRIC 1071(T) and Lactobacillus plantarum NRIC 1067(T). J Gen Appl Microbiol. 2002 Apr;48(2):91-102.

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