Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1205)
DME Name Beta-glucosidase (bglA), Bifidobacterium animalis
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; PG2010B_0119
Gene Name bglA
UniProt ID
A0A4Q4LS82_BIFAN
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Bifidobacterium animalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium animalis
Subspecies: Bifidobacterium animalis subsp. lactis Bi-07
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTMTFPKGFQFGTATAAYQIEGAVDEDGRTPSIWDVFSHTPGRVLNGDTGDKADDFYHRW
QDDLKLVRDLGVNAYRFSIGVPRVIPTPDGKPNEKGLDFYERIVDQLLEYGIDPIVTLYH
WDLPQYLNEDPYRGGWLNREIAFRMAEYAGIVAKRLGDRVHTYTTLNEPWCSAHLSYGGT
EHAPGLGAGPLAFRAAHHLNLAHGLMCEAVRAEAGAKPDLSVTLNLQVNRGDADAVHRVD
LIANRVFLDPMLRGYYPDELFAITKGICDWDFVHDGDLKLINQPIDVLGLNYYSTNLLAM
SDRPQFPQSTEASVAPGASDIDWLPTDGPHTQMGWNIDPDALYNTLVRLNDDYDHIPLVV
TENGMACPDEVEVGPDGVKMVHDDDRIDYLRRHLEAVHRAIEEGANVIGYFVWSLMDNFE
WAFGYDRRFGLTYVDYDTEERIRKDSYNWYRNFIAEHSAR
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
HY-N0040
 Drug Info Preclinical Rotavirus gastroenteritis ICD11: 1A22 [1]
Ginsenoside Rc
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [1]
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [1]
References
1 Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.

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