Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1210)
DME Name Beta-glucuronidase (uidA), Faecalibacterium prausnitzii
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852582_00799; uidA
Gene Name uidA
UniProt ID
A0A173S5S4_9FIRM
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Faecalibacterium prausnitzii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Faecalibacterium
Species: Faecalibacterium prausnitzii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRSIAKLMKDWQFTGPDGVTAAVALPHTWNAVDGQDGGNDYWRGTCIYRTSFAAPAFDPA
QQQVWLQFEGVNSSAAVLLNGQQLCTHDGGYSTFRAEITELLQAENQLTVRVDNSVNDRV
YPQKADFTFYGGIYRDVSLLVVNKNHIALGHFGDTGVKITPDLKEGSADIQVETLVEGEG
TVVVELLDAEGNSVARSEGAKASLHLDAPHLWNGVKDPYLYTCIVRLMQDGKPVDEVTTR
VGLRSFSVDAKKGFFLNGKPYPLHGVSRHQDRKGLGNAITREMHDEDMALIRELGANTVR
LAHYQHDQYFYDLCDKYGMVVWAEIPYISEHLPKGRENTISQMKELIHQNYNHPSIVCWG
VSNEITISTKDKADMLDNHRVLNELCHKMDPTRLTTLACYAMCGPFNSVAHITDLVSWNL
YLGWYVPGLFLNDLWMGFFHLVYPNRPLGFSEYGAEGMPNLHSAHPRRGDHTEEYQAKYH
EYMLKCFDRHPWLWATHVWNMFDFAADARDQGGEPGMNHKGLVTFDRKTKKDSFYLYKAW
WSEENFVHICSKRFTDRTEKEIEVKVYSNQKSVTLYADGKKLAEQTGEHIFKFRVPLHGK
VELKAVAGDCIDTACFRSVAAPNPSYKLVKTKSKSANWV
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Diclofenac glucuronide
 Drug Info Investigative Discovery agent ICD: N.A. [1]
PhIP glucuronide
 Drug Info Investigative Pancreatic cancer ICD11: 2C10 [2]
References
1 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
2 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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