Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1222)
DME Name Beta-lactamase (blaB), Empedobacter brevis
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase; EBR-1
Gene Name EBR-1
UniProt ID
Q8GQK7_9FLAO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Empedobacter brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Flavobacteriia
Order: Flavobacteriales
Family: Flavobacteriaceae
Genus: Empedobacter
Species: Empedobacter brevis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKLFSLIALIGSFAFGQIKPIQIDPINNNLFVYQTFNSFNGVEYNANGMYLVTNKGIVL
FDVPWQKSQYQELNDMLQEKYNLPVIAVFATHSHDDRAGDLSFYNELNIPTYATSLTNSK
LKKEGKATSKFEIELGKTYKFGNEKFVFEYFGEGHTSDNVVVWFPKYKVLNGGCLIKGAD
AVNLGYTGEANVVEWPKTVHKLVAKHPTIKQVIPGHDNWKATGHIENTFKLLEKK
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [1]
Cephalosporin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Carbapenem
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
References
1 EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7.

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