Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1224)
DME Name Beta-lactamase (blaB), Fusobacterium nucleatum
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; FN1584
Gene Name blaB
UniProt ID
Q8RIK5_FUSNN
Gene ID
992812
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Fusobacterium nucleatum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MEKYTEWKKEIEKIISQVDGKICINFYDLDKKNGFSINGNEKVLSASMIKLLILAELMKK
VSENKFSLSDTITITNFMKTGGDGVLKELNAGHHFTLKELATLMIIVSDNQATNILIDFL
GMENINFLGKELGLRETFLERRMMDAEASKNGYDNYTSADDISLLLKLIYQEKLINKETS
QLMLDILLRQQQGERLQRYLPPDIKIAHKCGDLDNLENDGGIIWLGNKIYILVVLTSGMS
NLQCRQTIGKISKFVYDKMEESLE
Pathway beta-Lactam resistance (fnu01501 )
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [2]
References
1 Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.
2 beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children. Antimicrob Agents Chemother. 1999 May;43(5):1270-3.

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