Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1226)
DME Name Beta-lactamase (blaB), Klebsiella oxytoca
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase OXY-1; bla
Gene Name bla
UniProt ID
BLO1_KLEOX
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella oxytoca     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella oxytoca
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MLKSSWRKTALMAAAAVPLLLASGSLWASADAIQQKLADLEKRSGGRLGVALINTADDSQ
TLYRGDERFAMCSTGKVMAAAAVLKQSESNPEVVNKRLEIKKSDLVVWSPITEKHLQSGM
TLAELSAAALQYSDNTAMNKMISYLGGPEKVTAFAQSIGDVTFRLDRTEPALNSAIPGDK
RDTTTPLAMAESLRKLTLGNALGEQQRAQLVTWLKGNTTGGQSIRAGLPASWAVGDKTGA
GDYGTTNDIAVIWPENHAPLVLVTYFTQPQQDAKSRKEVLAAAAKIVTEGL
Structure
3BYD
Function This enzyme hydrolyzes broad-spectrum beta-lactam antibiotics and is active against cephalosporins.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Piperacillin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [1]
Tazobactam
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
References
1 Characterization of piperacillin/tazobactam-resistant klebsiella oxytoca recovered from a nosocomial outbreak. PLoS One. 2015 Nov 5;10(11):e0142366.

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