Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1228)
DME Name Beta-lactamase (blaB), Plesiomonas shigelloides
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; pse4; NCTC10363_01512
Gene Name pse4
UniProt ID
A0A379CPC3_PLESH
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Plesiomonas shigelloides     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Plesiomonas
Genus: Plesiomonas
Species: Plesiomonas shigelloides
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKVLGRTFFRAAAVVISCWSLAGLAQSSLVKEQDTAALSAQVKSVEQTLGARVGVSVFIP
SQGVVWNYHGDQRFPMMSTFKTLACAKMLSDVDAGKLALNDTVKVRSEDLMEYSPVLRPL
AGTDITLQAACQATMETSDNTAANLVLEKIGGPAALTAYLQSIGDNVTRLDRNEPTLNEA
AKHDPRDTTTPNAINHTLNTLVLGETLSSTSRQQLKTWMQDNKVADGLLRSVLPQGVQIA
DRSGAGGFGSRGITALVWSAQQDPMFVSIYLTQTEATFDERNAAIVTIGKSIFDTFLTR
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Carbenicillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1], [2]
References
1 Beta-lactamase expression in Plesiomonas shigelloides. J Antimicrob Chemother. 2000 Jun;45(6):877-80.
2 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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