Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1275) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Lactobacillus johnsonii | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Lactobacillus johnsonii (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Flucytosine |
Drug Info | Approved | Cryptococcosis | ICD11: 1F27 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Tegafur |
Drug Info | Phase 4 | Colon cancer | ICD11: 2B90 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17. | ||||
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