Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1280)
DME Name Unclear metabolic mechanism (DME-unclear), Methanobrevibacter smithii
Gene Name DME-unclear
Lineage    Species: Methanobrevibacter smithii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Archaea
Phylum: Euryarchaeota
Class: Methanobacteria
Order: Methanobacteriales
Family: Methanobacteriaceae
Genus: Methanobrevibacter
Species: Methanobrevibacter smithii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          9 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Chloramphenicol
 Drug Info Approved Conjunctivitis ICD11: 9A60 [1]
Ofloxacin
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [1]
Tetracycline
 Drug Info Approved Spotted fever ICD11: 1C31 [1]
Rifampicin
 Drug Info Approved Osteoporosis ICD11: FB83 [1]
Amphotericin B
 Drug Info Approved Aspergillosis ICD11: 1F20 [1]
Gentamicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
Streptomycin
 Drug Info Approved Infectious endocarditis ICD11: BB40 [1]
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Trimethylamine oxide
 Drug Info Investigative Discovery agent ICD: N.A. [2]
References
1 The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J Antimicrob Chemother. 2011 Sep;66(9):2038-44.
2 Gut colonization with Methanogenic archaea lowers plasma trimethylamine N-oxide concentrations in apolipoprotein e-/- Mice. Sci Rep. 2018 Oct 3;8(1):14752.

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