| General Information of DME (ID: DME1305) |
| DME Name |
Glutamate decarboxylase (gadB), Shigella flexneri
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| Synonyms |
Glutamic acid decarboxylase; Bacterial glutamate--ammonia ligase; gad; gadB; GAD-beta; S4173; SF3594
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| Gene Name |
gadA
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 4.1.1.15 (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.15
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| Lineage |
Species: Shigella flexneri (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella flexneri
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MDQKLLTDFRSELLDSRFGAKAISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNL
ATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVG
TNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREI
PMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDM
HIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELV
FNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKQ
GPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVV
MRIMCRRGFEMDFAELLLEDYKASLKYLSDHPKLQGIAQQNSFKHT
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| Pathway |
Alanine, aspartate and glutamate metabolism (sfl00250 ) |
| Biosynthesis of secondary metabolites (sfl01110 ) |
| Butanoate metabolism (sfl00650 ) |
| Metabolic pathways (sfl01100 ) |
| Microbial metabolism in diverse environments (sfl01120 ) |
| Quorum sensing (sfl02024 ) |
| Taurine and hypotaurine metabolism (sfl00430 ) |
| beta-Alanine metabolism (sfl00410 ) |
| Function |
This enzyme converts glutamate to gamma-aminobutyrate (GABA). The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
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