Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1309)
DME Name Beta-lactamase (blaB), Alloprevotella tannerae
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase domain protein; GCWU000325_00085
Gene Name blaB
UniProt ID
C9LD75_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Alloprevotella tannerae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Alloprevotella
Species: Alloprevotella tannerae
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MLKIKRFIFNMVQENCYVLHDETQEGVIIDCGALMPEEEEALRDYIAAEGIQVKHLLHTH
SHFDHVFGDQFVYSTYGIKPEMHELEVALYGDVSGQVAMFLHRNISVVVPPLGNVFTGRD
EIKFGNHTLEIIETPGHSPGGVCFYCRAEKALFSGDSLFKHEIGRFDFPYGDGAALIDNL
KTKILTLPADVNVYPGHGDATSIEEERAYNPYLR
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204.

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