Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1314)
DME Name Beta-lactamase (blaB), Photorhabdus asymbiotica
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; PAU_00771; PA-RVA13-1244
Gene Name ampC
UniProt ID
B6VMJ3_PHOAA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Photorhabdus asymbiotica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Photorhabdus
Species: Photorhabdus asymbiotica
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MTKRFSVLTGSLLLAASLGVQASNTPDQTRLTNTVDKTIHSLMQEYDIPGMAIAVTFRGQ
HFFYQYGDASKESNTPVTKETIFELGSVSKTFAGSLISWAQVTGAISFSDKASQHFQPLA
GSAFDNINLLNIATYTAGGLPLQFPDEIDNNSKMVDWFQHWQPKYPPGTYRQYSNPSIGL
AGYIVAQRLEKPYSILVKNQILSPLGLHHTWFNVPAQEMKNYALGYSKENKPIRINPGVL
DEEAYGLKTSAQDLIGFVDANIDPSRVGDSKLAQAIRATHTGYYRTGEMTQGLGWELYHW
PVTLEQVLSGNSAEIAYQANKTTELSPPEPPTDALFINKTGSTNGFGAYVAFVPQEQMGI
VLLANKNYPNEARIKAAWQILKALK
Pathway Two-component system (pay02020 )
beta-Lactam resistance (pay01501 )
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1], [2]
References
1 Yersinia enterocolitica and Photorhabdus asymbiotica beta-lactamases BlaA are exported by the twin-arginine translocation pathway. Int J Med Microbiol. 2013 Jan;303(1):16-24.
2 Xenorhabdus luminescens (DNA hybridization group 5) from human clinical specimens. J Clin Microbiol. 1989 Jul;27(7):1594-600. Case Reports

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