Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1327)
DME Name Nitroreductase (NTR), Enterococcus casseliflavus
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; NCTC12362_00253
Gene Name nfrA2
UniProt ID
A0A377KR04_ENTCA
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Enterococcus casseliflavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNETIELLHNHRTYRQFDPDYRLSQEQVTAILTAARQAPSWMNGQAYSILVIDDPQIRQQ
MVEWNPGNPHIAACSLFLLFLADLNRTKKVADEKQTPYPIDEGYQPLLIATTDASIALQS
GAIAAESLGLGTVISGSVRKDSAKIAELLHLPEYVYPVAGLSIGKPIVEMKVKPRLPEEA
VIHYNHYQDYSYEAIEAYDQTMTAFGEARETKPWSEKFAGFYSNRPDQGFDAFLKKQNLI
K
Function This enzyme contains FMN and can utilize NADH and NADPH with similar reaction rates. It also reduces riboflavin and FAD, but more slowly.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrofural
 Drug Info Phase 3 Acute tonsillitis ICD11: CA03 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrobenzaldehyde
 Drug Info Investigative Discovery agent ICD: N.A. [2]
References
1 Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200.
2 ElNFS1, a nitroreductase gene from Enterobacter ludwigii, confers enhanced detoxification and phytoremediation of 4-nitrobenzaldehyde in rice

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