Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1336)
DME Name Beta-lactamase (blaB), Clostridium hiranonis
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaR1_1; CLOBL_05120
Gene Name blaR1_1
UniProt ID
A0A1S8TSZ5_9CLOT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Clostridium hiranonis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptostreptococcaceae
Genus: Clostridium
Species: Clostridium hiranonis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFKKLVFLGILLLPLILWIIWSNTSKNSSNSSMIYVEKNNENSEKVLNEDLSKYFSGYDG
CFVLYDKNENKYLIYNEAKSEKEISPCSTFKIVNALIGLDTNVLQDENTIFKWNGTKYAI
EEWNKDQTLSSAVANSVVWYFQDVASKVGEERMQEYLSKIDYGNKDISGGLTKFWLQSSL
KISPMQQVEILRNMYDYKLPFSRRNIDIVKKVLKISEQNGIVLSGKTGSGTDGNKSINGW
FIGYVESDNDVFFLAVNIEGKDNATGVLAEQIAKNILKDKNIL
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ceftiofur
 Drug Info Investigative Superficial thrombophlebitis ICD11: BD70 [1]
References
1 Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.

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