Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1338)
DME Name Linoleate 10-hydratase (10-LAH), Lactobacillus plantarum
Synonyms Linoleate hydratase; Oleate hydratase; Hydratase oleate; OA hydratase; Ohase; ohyA
Gene Name 10-LAH
UniProt ID
A0A1I9RYU9_LACPN
EC Number    EC: 4.2.1.84     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.84
Lineage    Species: Lactobacillus plantarum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus plantarum
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MVKSKAIMIGAGLSNMAAAVYLIQDGHWDGKDITFYGVDMHGANDGGATTDFTNEYWNKN
HPMANTTGYVARGGRMLNYRTYVDLMDLLDRIPSVTEPGMTAAEDTRDFDVKHRTYDIAR
LMQGGKGIINAGKLGFNNKDRTLLTKLIMMPDSEETKLDNVSIAEYFKDDPHMFQTNFWY
MWETTFAFRTQSSAQELRRYMHQMIYEFTQIEHLVGVNRTRYNQFESMILPLIKYLQGQG
VTFIDNKIVKDWQFKDTPMQDEITVTGLVIEDAQTGETEEVEVDEETAVIFTNGSITDSA
TMGDYNTPAPENMDYGVSASLWKKATERFYNLGTPDKFFNDRNASEWVSFTLTTKNHLFL
NEIVRITTQEPGNALNSFLSTTPITPLNQKDVNMSIVVHHQPHFTTQQPNETVLWGYFLY
PRRQGEFVNKPYIKMTGKEMAQELIGQLSKVDPGPGNIKDKEKEILDSIVNNIPVYMPYA
SALFNNRAKSDRPEVLPKHSTNLAFTGEFAEQPYQMIFTEQSAVRSGEIAAYHFAGVPMD
NLVKTPRYDKDPKTLLKATKKMFD
Function This enzyme catalyzes the conversion of linoleic acid to 10-hydroxy-12-octadecenoic acid.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Unifac-6550
 Drug Info Phase 1 Obesity ICD11: 5B81 [1]
References
1 Characterization of linoleate 10-hydratase of Lactobacillus plantarum and novel antifungal metabolites. Front Microbiol. 2016 Oct 4;7:1561.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.