Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1352)
DME Name Beta-glucuronidase (uidA), Bacteroides dorei
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; B5F00_14980; DWW04_15510; DXA69_19840; E1I72_12205; E1I98_19230; E1J02_10435; E1J03_18605; E1J06_16940; EAJ02_20045
Gene Name uidA
UniProt ID
A0A076IX12_9BACE
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Bacteroides dorei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides dorei
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKTLLTICLTWMCFSLSAQKIIDLSGKWSFSIDRQDNGEKEKWFSHTLNDCINLPGSMP
EKLKGDEVTAKTQWTGSLYDSSYYYNPYMEKYRKEGNIKFPFFLTPDKHYVGAAWYQKEV
NIPADWKGERILLFLERPHIETTVWVNGQKTGMQNSLCVPHQYDITRYVRPGKCTITIRV
DNRIKEINVGPDSHSITDQTQGNWNGIVGRICLQTTPKTYFDDIQIYPEPEQKLARVKVV
IKGAGITKIKLSAESFNTDKKHIVPAIQQEIKLNKGVTETEMVLPMGNDMLLWDEFHPAL
YKLKAEVTNGKKTEIKEIQFGMRRFEIKGKWFYVNGRKTQLRGTVENCDFPLTGYAPMDV
ESWERVFRICRSYGLNHMRFHSFCPPEAAFIAADRVGFYLQPEGPSWPNHGPKLGLGQPI
DTYLMNETIALTKEYGNYASYCMLACGNEPSGRWVEWVTKFVEYWEKKDPRHVYTGASVG
NGWQWQPRNQYHVKAGARGLTWSRRQPSTQDDYRFQNHLDTVKQPYVSHETGQWCAFPNF
NEIRKYTGVNKAKNFEIFKDILADNHMSDQAHLFMMASGKLQALCYKYEIEKTLRTPDYA
GFQLLALNDYSGQGTALVGVLDVFFEEKGYINSAEWRRFCSPTVPLMRTDKFVYNNNEIL
KADIEVAHFGAKTLKQAEIVYTLKDEYGKVYAQGTLATQDIPIGNLNHTGSLEFPLTDIQ
EAKKLNLEIRITGTEAVNDWNFWVYPAQVTIAEGKVYTTDTLDSKALEILQHGGNVLITA
AGKVSYGKEVVQQFTPVFWNTSWFKMRPPHTTGILVNPKHPLFRQFPTEYHSNLQWWELL
NHAQVMQFTHFPPAFQPTVQSIDTWFISRKIGMLFEANVLNGKVLMTSMDITSQPEKRIV
ARQMHKAILDYMNSDQFRPQFTVTPQQISELFTKTAGDIKSYTNDSPDELKPKIN
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diclofenac glucuronide
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.

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